Seanan McGuire (seanan_mcguire) wrote,
Seanan McGuire
seanan_mcguire

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BLACKOUT open thread!

To celebrate the release of Blackout, here. Have an open thread to discuss the book.

THERE WILL BE SPOILERS.

Seriously. If anyone comments here at all, THERE WILL BE SPOILERS. So please don't read and then yell at me because you encountered spoilers. You were warned. (I will not reply to every comment; I call partial comment amnesty. But I may well join some of the discussion, or answer questions or whatnot.)

You can also start a book discussion at my website forums, with less need to be concerned that I will see everything you say! In case you wanted, you know, discussion free of authorial influence, since I always wind up getting involved in these things.

Have fun!
Tags: blackout, mira grant, zombies
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Okay, so I had a bunch of stuff that really I should have been doing (especially since I'm abandoning my research student for four days between when I leave and when she leaves - we're sitting next to eachother getting pylab set up on her machine with a really awesomely distracting seminar on recent development going on in the auditorium right next to us - yeah, okay, I'm kind of bragging...) but instead I downloaded Blackout the moment I could, saying to myself "I'll read it on the plane tomorrow...!"

Ahem. Anyhow, all read now and I was only five minutes late this morning. (Though I only spent an hour doing forms practice this morning, promising myself I'd make it up later today. Hey, it could happen! After I get the peppers planted!)

And it was awesome, and I love it. I will love it even more when I've had a chance to go back over it and savor it. (Perhaps tomorrow, when I am stranged in O'Hare...)

I want to think more about the gradual release of information as it stands at the end of the book. Hm.

And inside George. So... self protective. Hm.

Minor note: There are some technical issues with the neuroscience as presented. Which is probably only a bugaboo of mine because I'm a neurobiologist. But, it occurred to me, especially as you are one step removed socially through a bunch of people* if you ever want someone to consult on the neuroscience side of things, I probably could at least help in the production as of technically accurate as far as we understand it and it's not that much sort of hand-waving. (Long term memory storage involves at least changes in protein conformation - it's not all electrical signals. A protein dynamics was just about my favorite thing ever back when I was a biochemist, I think this is about the coolest thing ever. Right up there with changes in ion channel conformation.)

* Folks? Back me up? Tell her I'm not craz- ...Um, tell her I'm harml- ...Um... Yeah, tell her something.
I so wish I'd known you were a neurobiologist! I did the best I could with the science I had, and yeah, I got a bunch wrong (although have you seen the electrical imaging studies with rats? Holy crap, that's why it wasn't nearly as fringe as it looked on the surface). I will totally tap you the next time I need to do anything with brains.

Actually, brains. How are you on the effects of toxoplasmosis on the human brain?
Honestly, it would be a lot of hand-waving in any case, because the kind of mimicking development* is something we totally don't know how to do. I'd like to think that by the time we got there we'd suck less at cloning, but where's my flying bike, anyway?

I've only followed toxoplasmosa casually, but yeah, at least somewhat - like the recent stuff on risk taking behavior? Fun stuff! Do you have a more defined question?

* That's really the biggie - making an adult from scratch? You'd have to have some way of stimulating the brain to make it think it had gone through years in that body, because the brain wires itself from experience at a really, really basic level.
Semi. Can you email me?
Sent you a note thru your site...
What is going on with toxoplasmosis in humans is that the parasite is trying to modify behaviour as though it were still in the normal small-rodent host, and getting things a little bit wrong. That it even gets a lot of things to work just shows how much brain chemistry is conserved in mammalian physiology; this isn't always the case. With parasites like loa-loa what you get is infected with a nematode parasite which isn't a human or even a primate parasite and once in humans gets a bit lost. The larval nematodes know that they have to migrate, and do just that (feeding along the way) but the biochemical markers that say "You have now arrived in the right spot to complete development" don't exist, so they just wander and wander.

To be honest, the notion of zombie-like behaviour being caused by a parasite has occurred to several authors before; "Night on Mispec Moor" by Larry Niven, for instance, but a parasite that acts somewhat like the Cordyceps fungi do on ants would be interesting to see.

There is also a school of thought expounded by myself and a friend, Mr Jon Downes, that quite a few of the supposed lake monsters of northern Europe and America can be explained as giant eels. European eels are strange creatures; they spawn in the Sargasso sea, then migrate to Europe across the Atlantic and enter river systems here, and spend years growing to a size at which they can spawn again. When this comes, a biochemical switch in their heads gets flipped (and can be flipped back to the "grow up" setting in a few cases) and they develop sexual characteristics, and migrate back to the Sargasso to breed and die.

It is a common characteristic of fish parasites, though, that they castrate their hosts. This in the case of eels (which I do not think are the principal host of this parasite, merely occasional victims) would prevent migration leaving the eel to live on, growing bigger, and bigger, and bigger. Captive eels have been recorded as surviving over thirty years; who knows how big a wild-living one could get?

BTW, I have a PhD in parasitology.
Actually, there is a zombie book about Cordyceps (That's the name of the book). Haven't read it yet, it's in the queue to read after Blackout.
If you, say, wanted to send me an email through my contact form, I could maybe be convinced to let you...fix...my science for Parasite.

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Ooo.

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