Do not want...but why not?

Ill-chosen character names are a bear for me, though this can take several forms. I've seen books in which characters have been named via spelling significant words backwards ("Nilrem" for a magician, "Krej" for a villain -- for a wonder, not in the same book). There was a book I had to check out of the library when I saw the review, just to confirm that the author really had stacked the Kryptonian Science Council with badly Tuckerized friends-and-editors. [I have no innate objection to Tuckerizations, not at all. Well done: David Weber's insertion of "Dr. Jordin Kare" into the Honorverse as a high-powered physicist. Badly done: see above.]

Inconsistent use of real-world settings: if you put the legendary Powell's Books into a novel set in Portland, and call it Powell's, excellent. If you put a bookstore that is clearly Powell's into a novel set in Portland, and call it something else, I will be tempted to throw things. (I have no problem whatsoever with inserting imaginary businesses and locations into real-world settings; that's often necessary for plot purposes. But using a real-world setting and then renaming key landmarks? Defeats the purpose and undercuts the suspension of disbelief. This is one thing that Rosemary and Rue did exceptionally well, at least for me.)

Willfully stupid characters: given a first-person narrative in which the reader can figure out what's going on by chapter five, the fact that the first-person narrator doesn't figure it out until chapter thirteen is likely to be a capital-P Problem. I am thinking of one new/current urban-fantasy series in particular, in which the author tries to deal with this by introducing a really clever twist to the way magic works...except that the twist is never applied sufficiently or thoughtfully enough to actually make the conceit work.

The key phrase there is "totally made-up"; in that instance, the key is preserving the atmosphere while creating something distinctive. In your case, too, you're talking about a major set/location, whereas in the book I'm thinking of the not-Powell's made a pretty much incidental appearance. It would be infinitely trickier to write a piece actually set in Powell's and bring it off. I have about half of a short story sitting on my hard drive that actually attempts this (it's stuck for other reasons); in that case I simply avoided using the name itself. That likely wouldn't work for a novel, but in the context of a short piece set entirely inside the store, it felt doable.

Willful stupidity is the absolute deal-killer for me. I put up with one recently where (first-person narration) I'd figured the shape of the story and most of the important plot points about a third of the book in, and it took Our Heroine until alllllmost the end. I put up with it, however, because Our Heroine was a realistically-portrayed fifteen, and it's not her fault she didn't know she was in a fairy tale, with all the logical plot constraints that implied.